Isotretinoin-Induced Elkonyxis

Isotretinoin-induced skeletal hyperostosis

We describe a case of skeletal hyperostosis in a 29 year old man presenting with non-inflammatory back pain with a past history of isotretinoin therapy for acne. The development of skeletal hyperostosis, predominantly of the spine, has been reported in association with isotretinoin use and has a radiographic picture similar to diffuse idiopathic skeletal hyperostosis. The prevalence and severit...

Isotretinoin-induced inflammatory bowel disease.

Three case reports on inflammatory bowel disease associated with use of isotretinoin are described. All three patients were male adolescents, in good health when starting isotretinoin (for acne treatment for about six months). Several weeks after discontinuation of isotretinoin the patients developed severe symptoms requiring hospitalisation. The diagnosis of ulcerative colitis was made in two ...

Isotretinoin induced rubber glove dermatitis.

Muscle damage induced by isotretinoin.

The absence of antibody to HTLV-I and HIV in patients with multiple sclerosis from France and similar findings in Italian patients (L ChiecoBianchi et al, personal communication) argue against these viruses having a role in the development of multiple sclerosis. Furthermore, the negative results in patients from the French West Indies, an area endemic for HTLV-I, strengthen the lack of a serolo...

Presumed isotretinoin-induced extraocular myopathy

Isotretinoin a synthetic analogue of vitamin A is primarily used for cystic acne not responding to conventional treatment. Several ocular side effects including blurring of vision, decreased dark adaptation, corneal opacities and meibomian gland atrophy have been reported with prolonged use of isotretinoin. There have been reports of muscular damage caused by isotretinoin. Extra ocular myopathy...